Originally established on Cork Street in 1958 as Waddington Galleries, Waddington Custot was formed in 2010 with the partnership of long-time London art dealer Leslie Waddington, and French art dealer Stephane Custot. Since becoming sole owner in 2015, Custot has welcomed renowned artists with whom he has a close connection, including Fabienne Verdier, Zao Wou-Ki, Hans Hartung, Chu Teh-Chun, Pierre Soulages and Bernar Venet. The gallery has since cultivated a rich heritage and an international reputation for expertise in outstanding works by modern and contemporary masters, with a particular focus on monumental sculpture.

The gallery continues to build on its sterling renown and over 60 years of experience, leading with high quality and well-researched exhibitions featuring significant artists of the mid-twentieth century and beyond. Today, Waddington Custot represents foremost contemporary and modern artists and their estates including David Annesley, Peter Blake, Patrick Caulfield, Ian Davenport, Allan D'Arcangelo, Robert Indiana, Jedd Novatt, Pablo Reinoso, Bernar Venet and Fabienne Verdier. The inventory includes works by important modern European artists including Josef Albers, Jean Dubuffet, Hans Hartung, Fausto Melotti, Joan Miró, Pierre Soulages and Maria Helena Vieira da Silva. The gallery's long-standing focus on heavyweight American artists continues through strong relationships with John Chamberlain, Peter Halley, Robert Rauschenberg, Frank Stella and John Wesley.